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Among these, CKD of unknown etiology (CKDu) is notable, especially widespread in agricultural communities, and caused by environmental factors such as agrochemicals, heavy metals, heat stress, herbal use, contaminated drinking water, and snake bites [39, 40]

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The reduction in skeletal muscle capillarization observed in our IGF- 1R KD model mirrors the capillary rarefaction seen in aging muscle, which has been linked to exercise intolerance and muscle wasting in older adults [58]

To elucidate potential mechanisms, the plasma metabolome of LC patients was investigated and compared to age-sex-matched acutely ill COVID-19, R, and HCs

They can secrete specific cytokines (TNF-, IL-4, IL-5, IL-13) or growth factors (vascular endothelial growth factor, fibroblast growth factor) to influence local immunity by promoting tissue repair in chronic inflammation or adjusting the balance between pro- and anti-inflammatory signals